Detection and Control of Ultrasonic Cavitation with Liposome
Date Issued
2004-09-30
Date
2004-09-30
Author(s)
DOI
922218E002044
Abstract
Cavitation based ultrasonic therapy has received considerable research attention for
noninvasive cancer treatment. The ultrasound’s low attenuation and focusing capabilities also
provide opportunities for site-specific treatment of deep-seated tumors. Cavitation is the
formation and activities of bubbles (or cavities) in a liquid. In order to make such a therapeutic
technique feasible, efficient induction and detection of cavitation is necessary, and these are also
the two main research goals of this project. Generally, acoustic cavitation is difficult to control
due to the inhomogeneous concentration distribution of cavitation nuclei in blood. On the other
hand, injection of microbubble based ultrasound contrast agent can provide a more uniform
distribution of cavitation nuclei. The strong scattering associated with contrast microbubbles can
also benefit detection of cavitation. In this project, we use Levovist® and liposome bubbles
(produced in house) as our cavitation nuclei. Special transmit waveforms are also designed for
effective induction of cavitation. For detection, the intensity change in B-mode and the inertial
cavitation dose are used. We have successfully built an experimental system and studied the
effects of pulse duration, duty cycle, frequency, phase and scanning sequence on cavitation
induction. In addition, a simulator based on the Rayleigh-Plesset equation and the Runge-Kutta
method has also been developed. The success of this preliminary project has built a solid
foundation for on-going and future research in cavitation based ultrasonic cancer therapy.
Subjects
ultrasound
contrast microbubbles
liposome
cavitation
cancer treatment
SDGs
Publisher
臺北市：國立臺灣大學電機工程學系暨研究所
Type
report
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