INCREASED LYMPHOCYTE SISTER CHROMATID EXCHANGE FREQUENCY IN WORKERS WITH EXPOSURE TO LOW LEVEL OF ETHYLENE DICHLORIDE
Resource
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 470 (2): 109-114
Journal
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Journal Volume
470
Journal Issue
2
Pages
109-114
Date Issued
2000
Date
2000
Author(s)
CHENG, TSUN-JEN
Abstract
The genotoxicity of low-level exposure to ethylene
dichloride (EDC) and vinyl chloride monomer (VCM) in humans
is not clear. We used lymphocyte sister chromatid exchange (
SCE) frequency as a parameter to investigate the
genotoxicity of low level EDC and VCM in VCM-manufacturing
workers. The SCE frequency was determined for 51 male
workers with exposure to VCM and/or EDC and for 20 male
workers devoid of such exposure. Epidemiological data were
obtained by questionnaire, and included history of smoking,
drinking, and any medication taken, as well as a detailed
occupational history. Personal- and area-sampling and
analysis were conducted in order to calculate the time-
weighted average (TWA) contaminant-exposure level
corresponding to different job categories. Moderate EDC
exposure around 1 ppm corresponded to a significantly
greater SCE frequency than was the case for the low EDC
exposure group (p<0.01). However, VCM exposure of similar
level was not associated with increased SCE. We conclude
that EDC may cause genotoxicity at a relatively low level of
exposure. (C) 2000 Elsevier Science B.V. All rights
reserved.
Subjects
sister chromatid exchange
smoking
vinyl chloride
ethylene dichloride
Type
journal article
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