Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: A prospective study
Journal
PLoS ONE
Journal Volume
9
Journal Issue
1
Pages
e86797
Date Issued
2014
Author(s)
Abstract
Background: We hypothesized that cord blood hydrogen peroxide (H2O2 ) could be utilized to predict the severity of neonatal hyperbilirubinemia. Methods: We prospectively enrolled term or near-term healthy neonates. Cord blood and capillary blood at three days of age were measured for hydrogen peroxide and bilirubin concentrations. For newborns with hyperbilirubinemia, further blood samples were obtained at five and seven days of age. Newborns were divided into severe or less severe hyperbilirubinemic groups (peak bilirubin ?17 mg/dL or not). The sensitivity, specificity, and negative predictive values were determined. Results: There were 158 neonates enrolled. The incidence of neonatal hyperbilirubinemia was 30.5% for a concentration ?15 mg/dl. The rising patterns were similar among bilirubin concentrations and hydrogen peroxide levels during the first few days of life. There was a strong positive correlation between bilirubin concentrations and hydrogen peroxide levels after correlation analysis. The rate of severe hyperbilirubinemia was 13.3%. It revealed that a cord blood hydrogen peroxide signal level of 2500 counts/10 seconds was an appropriate cut-off for predicting severe hyperbilirubinemia. Sensitivity and the negative predictive value were 76.2% and 93.3%, respectively. Conclusions: Our findings confirm that hydrogen peroxide levels and bilirubin concentrations in cord and neonatal blood are closely related. A cord blood hydrogen peroxide level above 2500 counts/10 seconds associated with a high predictive value for severe hyperbilirubinemia. This method provides information about which neonate should be closely followed after discharge from the nursery. ? 2014 Chou et al.
SDGs
Other Subjects
bilirubin; hydrogen peroxide; article; bilirubin blood level; blood level; blood sampling; capillary blood; controlled study; disease severity; human; major clinical study; neonatal hyperbilirubinemia; newborn; predictive value; prospective study; receiver operating characteristic; sensitivity and specificity; umbilical cord blood; Bilirubin; Biological Markers; Fetal Blood; Follow-Up Studies; Gestational Age; Humans; Hydrogen Peroxide; Hyperbilirubinemia, Neonatal; Incidence; Infant, Newborn; Predictive Value of Tests; Prospective Studies; ROC Curve; Taiwan
Publisher
Public Library of Science
Type
journal article