The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition
Journal
Journal of Biomedical Science
Journal Volume
29
Journal Issue
1
Date Issued
2022-06-28
Author(s)
Chen, Jia-Huang
Wu, Chia-Hsien
Jheng, Jia-Rong
Abstract
The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transition from acute kidney injury (AKI) to chronic kidney disease (CKD).
Subjects
Acute kidney injury; Chronic kidney disease; Fibrosis; Unfolded protein response; XBP1
SDGs
Publisher
BMC
Type
journal article