ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking
Journal
Journal of biomedical science
Journal Volume
30
Journal Issue
1
Date Issued
2023-02-19
Author(s)
Chiu, Chu-Hsuan
Hsuan, Chin-Feng
Lin, Shih-Hua
Hung, Yi-Jen
Hwu, Chii-Min
Hee, Siow-Wey
Fong, Sitt-Wai
Hsieh, Patrick Ching-Ho
Lee, Hsiao-Lin
Hsieh, Meng-Lun
Hsu, Chih-Neng
Abstract
Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood pressure is unknown.
Subjects
Arrhythmia; Blood pressure; Cardiovascular disease; Hyperkalemia; Hyporeninemic hypoaldosteronism; RRBP1; Renin–angiotensin–aldosterone system
Publisher
BMC
Type
journal article