光動力及高溫對於細胞胞飲作用的影響
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
王正一
DOI
932213E002085
Abstract
Photodynamic therapy (PDT) is a promising new treatment for cancer that has been
recently accepted in the clinic. PDT involves the localization of a light-sensitive drug in the
target tissue prior to illumination using an appropriate wavelength. Exposure of tissue
containing a sufficient concentration of photosensitizer to irradiation of adequate wavelengths
initiates photodynamic activation to generate single oxygen free radicals and other reactive
species, causing cellular damage and tissue necrosis. It is a procedure having the potential to
selectively destroy malignant tissues without causing serious damage to the adjacent normal
structures if light dosimetry can be delivered with care. PCI is a novel method that can release
macromolecules from endocytic vesicles by introducing photochemical damage to the
membranes of these vesicles.
In this project, the effects of PCI combine with hyperthermia on cellular uptake or
endocytosis will be studied by PAMAM-FITC monitoring.
Subjects
photochemical internalization
hyperthermia
cellular uptake
endocytosis
dendrimer
SDGs
Publisher
臺北市：國立臺灣大學醫學工程學研究所
Type
report
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