Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease
Journal
Respiratory Research
Journal Volume
20
Journal Issue
1
Date Issued
2019
Author(s)
Abstract
Background and objective: Among patients with chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM) is a common comorbidity and is probably associated with increased systemic inflammation and worse prognosis. Metformin, with its pleiotropic anti-inflammatory and antioxidant actions, may offer theoretical benefits in COPD patients with DM. Thus, this study aimed to investigate the effects of DM and metformin use on mortality in the clinical trajectory of COPD. Methods: This was a retrospective cohort study comprising patients with spirometry-confirmed COPD and an age of ≥40 years from 2008 to 2014. The primary outcome of interest was all-cause mortality. We evaluated the effects of DM on mortality through the clinical course of COPD and we also assessed the impact of metformin use on survival of the COPD population. Results: Among 4231 COPD patients, 556 (13%) had DM, and these patients had 1.62 times higher hazards of 2-year mortality than those without DM (95% confidence interval [CI], 1.15-2.28) after adjusting for age, gender, COPD stage, comorbidities and prior COPD hospitalization. Over a 2-year period, metformin users had a significantly lower risk of death (hazard ratio, 0.46; 95% CI, 0.23-0.92) compared with non-metformin users in patients with coexistent COPD and DM. Moreover, metformin users had similar survival to COPD patients without DM. Conclusions: This study shows that DM is associated with an increased risk of death in COPD patients and metformin use seems to mitigate the hazard. Our findings suggest a potential role of metformin in the management of DM in COPD. © 2019 The Author(s).
Subjects
Chronic obstructive pulmonary disease; Comorbidity; Diabetes mellitus; Metformin; Outcome
SDGs
Other Subjects
metformin; antidiabetic agent; metformin; adult; adverse outcome; age; Article; cause of death; chronic obstructive lung disease; clinical outcome; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease course; drug use; female; gender; high risk patient; hospitalization; human; low risk patient; major clinical study; male; mortality risk; outcome assessment; prognosis; retrospective study; spirometry; survival time; aged; chronic obstructive lung disease; diabetes mellitus; middle aged; prognosis; very elderly; Aged; Aged, 80 and over; Cohort Studies; Comorbidity; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prognosis; Pulmonary Disease, Chronic Obstructive; Retrospective Studies
Publisher
BioMed Central Ltd.
Type
journal article