Fabrication and Microfluidic Investigation of Porous Materials for Bio-chip Applications
Date Issued
2009
Date
2009
Author(s)
Chen, Tz-Shian
Abstract
A bio-chip with the capability of conducting blood separation for whole blood diagnostics has been proposed in this study. Blood cells and serum are separated by embedding filters in the microchannel. The filter have been fabricated and evaluated. The filter is made of porous nylon with the pore size of about 100 nm. Specific antibodies in the serum can pass through the filter. The microchannel which contains the filter has been properly designed so that the serum flow is facilitated by the capillary force. The fabricated device is disposable and can be potentially applied in point-of-care diagnostics or micro total analysis system (μTAS). And base on the surface energy theory to model and analyze the liquid flow in a capillary. Final, an observation experiment of measuring the variation of meniscus in a capillary is set up. By capturing the figures of meniscus shape, analyze the meniscus variation and compare the experiment data with the model solution.
Subjects
porous
separation
capillary
surface energy
meniscus
pressure barrier
Type
thesis