Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo
Journal
Science Advances
Journal Volume
8
Journal Issue
3
Pages
eabl8096
Date Issued
2022
Author(s)
Cheng S.-H.
Lin Y.-S.
Shentu T.-P.
Huang R.-T.
Zhu J.
Chen Y.-T.
Kumar S.
Huang P.-H.
Roselló-Sastre E.
Garcia F.
Jo H.
Fang Y.
Abstract
mice. These results delineate a new molecular paradigm that DF-induced endothelial TXNDC5 promotes atherosclerosis and establish a proof of concept of targeting endothelial mechanosensitive pathways in vivo against atherosclerosis.
SDGs
Type
journal article