Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations
Journal
ESMO open
Journal Volume
7
Journal Issue
2
Date Issued
2022-04
Author(s)
Solomon, B J
Loong, H H
Summers, Y
Thomas, Z M
French, P
Lin, B K
Sashegyi, A
Wolf, J
Drilon, A
Abstract
The number of randomized trials of agents targeting oncogene-addicted tumors has surged in the past 10 years. Using a meta-analysis, we explored whether improvements in objective response rate (ORR) in comparative trials using targeted agents could serve as a potential surrogate endpoint for improvements in progression-free survival (PFS) or overall survival (OS) in populations with oncogene-addicted cancer.
Subjects
correlation; meta-analysis; objective response rate; overall survival; progression-free survival; targeted therapy
SDGs
Publisher
ELSEVIER
Type
journal article