經導管轉植血管生長素基因及骨髓幹細胞進行治療性心肌血管新生
Other Title
Therapeutic Myocardial Angiogenesis by Catheter-Based
Transfer of Vascular Growth Factor Gene and Bone Marrow
Stem Cells
Transfer of Vascular Growth Factor Gene and Bone Marrow
Stem Cells
Date Issued
2002
Date
2002
Author(s)
李啟明
DOI
902314B002240
Abstract
Therapeutic angiogenesis, in the form of
growth factor protein administration or gene
therapy, has emerged as a new horizon of the
treatment of patients with severe, inoperable
coronary artery disease. Improved myocardial
perfusion and function after the
administration of angiogenic growth factors
or gene transfer, such fibroblastic growth
factors (FGFs), vascular endothelial growth
factors (VEGFs), has been demonstrated in
animal models of chronic myocardial
ischemia models. Angiogenesis by gene
transfer is currently under investigation using
a variety of growth factors, the way of gene
transfer and a wide array of potential delivery
system. These include application of gene as
naked DNA, or by viral vector. The deliver
systems include intracoronary,
intrapericardial, direct intramyocardial
techniques. The significance of endothelial
progenitor cells in the enhancement of
neovascularization is also promising.
However, the optimal way to achieve the
"functional and sustainable" angiogenesis is
still unclear.
We propose that administration of
replication-deficient adenovirus vector
expressing VEGF165 cDNA in combination
with vascular endothelial progenitor cells
directly into ischemic myocardium which is
defined by catheter-based electromechanical
mapping would enhance collateral vessel
formation, regional myocardial perfusion,
and cardiac function.
Subjects
Coronary artery disease
angiogenesis
endothelial
progenitor cells
progenitor cells
gene therapy
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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