Multishelled Hollow Silica Nanospheres with Programmable Encapsulation and Tumor-Responsive Catalytic Activities
Journal
ACS Applied Nano Materials
Journal Volume
8
Journal Issue
17
Start Page
8676
End Page
8689
ISSN
2574-0970
2574-0970
Date Issued
2025-04-24
Author(s)
Abstract
Multishelled hollow silica nanospheres (HSNs) have emerged as a promising class of hierarchical nanostructures for applications in tumor therapy, cascade catalysis, and biomedical engineering, owing to their large surface areas, tunable architecture, and spatial compartmentalization. Here, we present a one-pot strategy based on a water-in-oil reverse microemulsion system for the scalable synthesis of multishelled HSNs with precise control over shell number, thickness, intershell spacing, and particle size (sub-100 nm), alongside in situ surface PEGylation for enhanced colloidal stability. This approach enables the production of high-yield, uniform single-shelled HSNs and structurally customizable variants with up to four concentric shells. MnOx-doped double-shelled HSNs exhibit tumor microenvironment-responsive catalytic activity, including hydrogen peroxide-driven oxygen generation and macrophage polarization, highlighting their relevance in immunomodulatory cancer therapy. Furthermore, spatially resolved encapsulation of hydrophilic (Au, Ag) and hydrophobic (FeOx) nanoparticles within discrete compartments demonstrates the platform’s capacity for compartmentalized loading, supporting applications in cascade catalysis and sequential drug delivery. By overcoming key limitations in scalability, dispersibility, and functional integration, this work establishes a robust and versatile nanofabrication framework for the development of next-generation silica-based nanocarriers in therapeutic and catalytic domains.
Subjects
compartmentalized nanoparticle integration
hierarchical nanostructure design
multishelled hollow silica nanospheres
tumor-responsive nanocarriers
W/O reverse microemulsion
Publisher
American Chemical Society (ACS)
Type
journal article