Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery.
Journal
Scientific reports
Journal Volume
15
Journal Issue
1
ISSN
2045-2322
Date Issued
2025-03-26
Author(s)
Yang, Tsung-Mu
Chen, I-Hsuan Alan
Yu, Chia-Cheng
Yang, Chi-Rei
Chen, Wen-Chi
Lin, Po-Hung
Pang, See-Tong
Huang, Steven Kuan-Hua
Chen, Zhi-Hao
Tseng, Jen-Shu
Lin, Wun-Rong
Tsai, Yao-Chou
Yu, Chih-Chin
Chen, Pi-Che
Cheong, Ian-Seng
Jiang, Yuan-Hong
Wu, Chia-Chang
Huang, Hsu-Che
Tai, Ting-En
Lin, Wei-Yu
Chen, Yung-Tai
Wu, Richard Chen-Yu
Lee, Hsiang-Ying
Yeh, Hsin-Chih
Abstract
Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0-1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.
Subjects
Eastern cooperative oncology group
Major perioperative complication
Radical nephroureterectomy
Survival outcome
Upper tract urothelial carcinoma
Type
journal article