Reproducibility of the Perfusion-related Diffusion Coefficient in Liver Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging: Considering Image SNR, b value Sampling Numbers and the Existence of Larger Vessel
Date Issued
2015
Date
2015
Author(s)
Han, Hung-Shih
Abstract
Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM DW MRI) is a technique that can quantitatively assess both the water molecular diffusion in static tissues (true diffusion coefficient, D) and the incoherent motion of blood water molecules in capillary networks due to perfusion (pseudo-diffusion coefficient, D*). However, D* value in liver parenchyma appears to be of high uncertainty among literatures. The aim of this study is to determine the reproducibility of D* in normal liver at 3T, considering SNR, b value sampling numbers and the existence of large vessel in ROI. A modified fit approach combined with an error evaluation method was proposed. Through the proposed method, the reproducibility of D* in 6-time-averaged liver images improved. Future studies can utilize this procedure for IVIM liver investigation while the scanning time can still be further optimized.
Subjects
Intravoxel Incoherent Motion
Diffusion-weighted Magnetic Resonance Imaging
Liver
Reproducibility
Type
thesis
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