In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods
Journal
Optics Express
Journal Volume
13
Journal Issue
23
Pages
18605-18615
Date Issued
2008-11
Author(s)
Abstract
The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated. ? 2008 Optical Society of America.
SDGs
Other Subjects
Diseases; Electromagnetic wave absorption; Gold; Light absorption; Molecules; Nanorods; Optical properties; Plasmons; Cancer cells; Cancer diagnosis; Contrast Enhancement; Imaging experiments; Laser wavelength; Molecular signatures; Optical absorption properties; Target molecule; Molecular imaging; antibody; diagnostic agent; epidermal growth factor receptor; gold; nanomaterial; animal; article; chemistry; computer aided design; drug delivery system; echography; elastography; equipment; equipment design; genetic procedures; human; immunology; instrumentation; male; metabolism; methodology; mouse; mouse mutant; mouth tumor; reproducibility; sensitivity and specificity; system analysis; ultrastructure; Animals; Antibodies; Computer-Aided Design; Drug Delivery Systems; Elasticity Imaging Techniques; Equipment Design; Equipment Failure Analysis; Gold; Humans; Male; Mice; Mice, SCID; Molecular Probe Techniques; Mouth Neoplasms; Nanostructures; Receptor, Epidermal Growth Factor; Reproducibility of Results; Sensitivity and Specificity; Systems Integration
Type
journal article