全身性紅斑狼瘡病人多形核嗜中性白血球趨化激素受器的表現及其對趨化激素的反應
Date Issued
2003
Date
2003
Author(s)
謝松洲
DOI
912314B002177
Abstract
Defective phagocytosis, decreased IL-8 production, and hyporesponsiveness to
IL-8 stimulation are important factors predisposing systemic lupus patients (SLE)
susceptible to bacterial infections. For elucidating the molecular basis of functional
inertia in neutrophils of SLE (SLE-PMN), the expression and modulation of IL-8
receptors, and the responsiveness of IL-8 stimulation of these cells were determined.
We found the membrane expression of CXCR2, but not CXCR1, was decreased but
cytosolic CXCR2 was increased in SLE-PMN compared to normal PMN. However,
the binding affinity of the CXCR2 with IL-8 was not different in both PMNs. By
contrast, the IL-8-induced CXCR2 down-regulation in SLE-PMN was decreased
because of decreased internalization and impaired proteolytic cleavage of the
ligand-receptor complexes by the cells. In addition, the expression of CXCR2 in
response to genistein, cycloheximide and catalase, but not superoxide dismutase, was
also different between the two cells. In conclusion, defective expression of CXCR2
including the hypo-responsiveness and abnormal transport render the functional
inertia in SLE-PMN.
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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