Characteristics and safety of nano/submicron cellulose
Date Issued
2007
Date
2007
Author(s)
Liu, Ying-Yin
DOI
zh-TW
Abstract
In this research, nano/submicron cellulose suspension is produced by “top-down” approach of media milling. In this approach, raw cellulose is degraded by mechanical force, and its characteristics and safety is investigated as well. In addition, the morphological differences between raw and nano/submicron cellulose in suspension, freezed-dried powder and hot-air dried powder are also examined. The aggregation in cellulose suspension is observed by optical microscopy. The surface properties of freezed-dried and hot-air dried powder are observed by SEM. The produced Nano/submicron cellulose by media milling was morphologically different from raw cellulose, and the particle size lied in nano/submicron scale is reconfirmed by laser diffraction particle size analyzer. The water-holding capacity of milled cellulose is found to be 8.5 times higher than raw cellulose, and also reaches consistency with the increase of specific surface area. As for safety assessment, the mutagenicity is evaluated by Ames test. The results show that there is no genotoxicity in Salmonella typhimurium TA98 and TA100. Cytotoxicity is also investigated in vitro. For portal-of-entry toxicity of skin and entero-mucosa, there is no significant cytotoxic effect on rat normal small intestinal cell line IEC-6, human skin fibroblast WS1 and human colon adenocarcinoma Caco-2 from nano/submicron cellulose. Furthermore, antimutagenicity of nano/submicron cellulose against 4-NQO is also considered. The data shows that there is no significant antimutagenicity in TA98 strain, but a slight antimutagenic reveals in TA100 strain.
Subjects
奈米
介質研磨
纖維素
保水力
細胞毒性
基因毒性
nanotechnology
media-milling
cellulose
cytotoxicity
genotoxicity
Type
thesis
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