Effects of ranibizumab on human corneal endothelial cells
Journal
Taiwan Journal of Ophthalmology
Journal Volume
4
Journal Issue
3
Pages
120-122
Date Issued
2014
Author(s)
Abstract
Purpose: This study aims to evaluate corneal endothelial changes occurring over a 3-month period after intravitreal injections of ranibizumab in patients with wet age-related macular degeneration. Methods: This is a prospective case series. A total of 29 patients (29 eyes) received a 0.5-mg intravitreal injection of ranibizumab. Specular microscopy, including measurement of central corneal thickness and endothelial cell count, was performed on each patient prior to and after completing three intravitreal injections. Results: All patients received three intravitreal injections and were followed up for a mean of 3months. There was no significant change in corneal thickness (p=0.32) or endothelial cell density (p=0.38) after ranibizumab injections. Conclusion: Intravitreal ranibizumab injections (0.5mg) have no harmful effects on corneal endothelial cells.
Type
journal article