Electrocatalytic CuBr@CuO nanoparticles based salivary glucose probes
Journal
Biosensors and Bioelectronics
Journal Volume
194
Date Issued
2021
Author(s)
Abstract
Highly electrocatalytic cuprous halide/copper oxide nanoparticles (CuX@CunO NPs; X = Cl, Br or I; n = 1 or 2) have been fabricated on copper foils for sensitive detection of glucose. Formation of CuX@CunO NPs involves two steps– in situ electrochemical deposition of CuX on the foil and then conversion of CuX to CunO. The deposited CuX converts to CunO, leading to the generation of abundant oxygen vacancies in the CuO lattice, enhancing the number of catalytically active sites, and improving the charge transfer efficiency. Among the as-prepared electrodes, CuBr@CuO NP ones provide the highest electrocatalytic activity toward the oxidation of glucose. The electrode provides electrocatalytic activity toward the oxidation of glucose at a low overpotential of 0.25 V (vs. SCE), which is lower than that (0.40 V) of unmodified copper electrodes. The generated anodic current is proportional to glucose concentration in an alkaline medium, with a good linear range from 5.0 μM to 3.51 mM (R2 = 0.995). Its reliability has been validated by detecting the glucose concentration in saliva samples at different time intervals after a meal. The results are in good correlation with the blood glucose level determined by using a commercial blood glucose meter. Our CuBr@CuO NP electrode possesses great potential for monitoring salivary glucose to achieve the purpose of noninvasive glucose monitoring for patients with diabetes in the future. ? 2021 Elsevier B.V.
Subjects
Copper halide
Copper oxide
Glucose probe
Oxygen vacancies
Salivary samples
Blood
Bromine compounds
Charge transfer
Electrochemical deposition
Glucose
Nanoparticles
Reduction
Copper foils
Copper oxide nanoparticles
CuO nanoparticles
Cuprous halides
Electrocatalytic
Electrocatalytic activity
Glucose concentration
Salivary sample
Copper oxides
copper
cupric oxide
glucose
nanoparticle
blood glucose monitoring
genetic procedures
glucose blood level
human
reproducibility
Biosensing Techniques
Blood Glucose
Blood Glucose Self-Monitoring
Copper
Humans
Reproducibility of Results
SDGs
Type
journal article