Preparation of Phenylenediamine Compounds for Conjugation with Ketoacid Saccharides and Peptides
Date Issued
2007
Date
2007
Author(s)
Tseng, Chun-Hao
DOI
zh-TW
Abstract
In this thesis, we plan to use a simple linker which can directly conjugate with sugar and peptide without any modification on the peptide and saccharide.
Compound 1 is the crosslinker designed for conjugation with unmodified sialic acid and peptide. Compound 1 reacted with sialic acid to give quinoxalinone derivatives 22.
Compound 26 underwent photoligation with n-butylamine to give 3H-azepine derivatives 27, and the gradual disappearance of the azido phenyl group was shown by the UV-Vis spectrum.
Subjects
唾液酸
連接試劑
喹
喔啉
酮
疊氮苯
胜肽
sialic acid
crosslinker
quinoxalinone
photoligation
peptide
Type
thesis
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