Effects of electrical field on the behavior of biological cells
Journal
Finely Dispersed Particles: Micro-, Nano-, and Atto-Engineering
Pages
683-714
ISBN
9781420027662
9781574444636
Date Issued
2005
Author(s)
Kuo Y.-C.
Abstract
Over the past century, the interdisciplinary knowledge about colloids and interfacial phenomena has gradually developed into a prosperous field in science and engineering. Both theoretical development and experimental study on macroscopic and microscopic systems have become a great significance [1]. Recently, the issues related to biological cells have attracted much attention for fundamental research and application. For the interaction between biological cells and bio- interfaces or among cells, deposition, adsorption, and flocculation are the most important phenomena. The knowledge about deposition of cells onto various bio-surfaces is crucial to understand numerous physiological disorders commonly encountered in practice, for example, the secondary tumor growth. Cancer cells are transported by blood circulation from the position of primary tumor to the vascular endothelium of other body tissues during the spread of malignant tumor. For the deposition of biological cells, two stages are in series, migration to the vicinity of a solid interface by external field followed by adhesion, are the widely adopted mechanisms [2]. Also, investigations on bio-adsorption behavior and flocculation among biological cells in an electrolyte solution are essential in understanding the biomedical performance of cells. Obser- vations for bio-adsorption phenomena include adherence of platelets on a blood-vessel lumen to generate embolisms [3], adhesion of bacteria on a tooth wall to erode dental enamels [4], and adsorption of various proteins on an air-water interface to form bubbles [5]. In industrial process, immobilization technique of microbes on microcarriers in a bioreactor plays an important role. In addition, typical examples for bio-flocculation are: abnormal aggregation of dysfunctional platelets inside pathological blood-vessel, yielding fatal consequences like thrombogenesis or cor- onary thrombus formation and bleeding, and collagen self-assembly under physiological condition in connective tissue. ? 2006 by Taylor & Francis Group, LLC.
SDGs
Type
book part