RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling
Resource
BMC Genomics 7: 317
Journal
BMC Genomics
Journal Volume
7
Journal Issue
317
Pages
1-7
Date Issued
2006
Date
2006
Author(s)
Abstract
Background: Many marketed therapeutic agents have been developed to modulate the function of G protein-coupled receptors (GPCRs). The regulators of G-protein signaling (RGS proteins) are also being examined as potential drug targets. To facilitate clinical and pharmacological research, we have developed a novel integrated biological database called RINGdb to provide comprehensive and organized RGS protein and GPCR information. Results: RINGdb contains information on mutations, tissue distributions, protein-protein interactions, diseases/disorders and other features, which has been automatically collected from the Internet and manually extracted from the literature. In addition, RINGdb offers various user-friendly query functions to answer different questions about RGS proteins and GPCRs such as their possible contribution to disease processes, the putative direct or indirect relationship between RGS proteins and GPCRs. RINGdb also integrates organized database cross-references to allow users direct access to detailed information. The database is now available at http://ringdb.csie.ncu.edu.tw/ringdb/. Conclusion: RINGdb is the only integrated database on the Internet to provide comprehensive RGS protein and GPCR information. This knowledgebase will be useful for clinical research, drug discovery and GPCR signaling pathway research. ? 2006 Fang et al; licensee BioMed Central Ltd.
SDGs
Other Subjects
G protein coupled receptor; RGS protein; amino acid sequence; article; data extraction; information retrieval; information storage; Internet; mutation; protein database; protein domain; protein localization; protein processing; protein protein interaction; RINGdb; tissue distribution; Amino Acid Sequence; Animals; Databases, Protein; Drug Design; Humans; Internet; Mice; Mutation; Organ Specificity; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Rats; Receptors, G-Protein-Coupled; RGS Proteins; Signal Transduction
Type
journal article
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