行政院國家科學委員會補助專題研究計畫成果報告:感光細胞-色素上皮細胞-脈絡膜複合體之退化與高度近視黃斑部變性之關係 (3/3)
Date Issued
2000
Date
2000
Author(s)
何子昌
DOI
892314B002002
Abstract
high myopic maculopathy, macular degeneration, retinal pigment
epithelium, extracellular matrix, retinal transplantation
high myopic maculopathy may cause the loss os central vision and is the
leading cause of blindness in taiwan.
Unfortunately, there are still several topics need to be resolved in
dealing with this most serious complication of high myopia: (1) The
pathogenesis of high myopic maculopathy remains unknow. (2) The need for
an animal model of high myopic maculopathy exists. (3) Untill now there
is no effective treatment for high myopic maculopathy. First of all, we
would start by using an in vitro method to study the cause of it. There
has been tremendous breakthroug in the study of the pathogenesis of
macular degeneration in recent years. We planned to study the defects and
relationships of the these cellular layess in the photoreceptors-retinal
pigment epithelium-choriocapillais complex. Secondly, we would study the
structural changes in the eyeball of form- deprivation myopia. On the
basis of the findins the previous steps, we would study the functional
defect of the high myopia eyes by an organ culture technique, e.g. the
reattachment, growth and proliferation of retinal pigment epithelium on
the substrates, The aim is to establish an animal model for high myopic
maculopathy. Thirdly, we would transplant retinal pigment epithelium to
the subretinal space of high myopic eyes by a microsurgical delivery
technique in combination with the necessary factors found in the previous
studies, e.g. extracellular matrix and/or growth factors.
Our results showed that the rupture of elastic membrane is the first
sign of Bruch’s membrane degeneration by 8 weeks, however the reattachment
efficiency of RPE to Bruch’s membrane were decreased since 2 weeks after
form- deprivation. In the rescue of macular degeration, the combined
RPE-Extracellular matrix transplautation technique we developed and
published peuiously serue as a novel method in the rescue of photoreceptor
cells in large myopic eyes of DBA/2J mice.
Publisher
臺北市：國立臺灣大學醫學院眼科
Type
journal article
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