Direct Conversion of Aldehydes to Amides, Tetrazoles, and Triazines in Aqueous Media by One-Pot Tandem Reactions
Resource
Journal of Organic Chemistry 68: 1158-1160
Journal
Journal of Organic Chemistry
Journal Volume
68
Journal Issue
3
Pages
1158-1160
Date Issued
2003
Date
2003
Author(s)
Shie, Jiun-Jie
Abstract
A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by extraction or filtration.
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Type
journal article
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