In-Vivo Skin Measurement Using High Definition Mirau-based Full Field Optical Coherence Tomography
Date Issued
2015
Date
2015
Author(s)
Wu, Dong-Yi
Abstract
Skin biopsy is the gold standard for doctors to diagnosis skin cancers. There are several ways to do a skin biopsy such as punch biopsy, shave biopsy, incisional biopsy. These methods are all invasive that make the patient bleed and leave scar. Optical coherence tomography (OCT) is one of the most important techniques in biomedical imaging realm. It is a noninvasive, label-free, and 3D imaging method. In this thesis, a homemade Ti:sapphire crystal fiber amplified spontaneous emission (ASE) light source was used to build a Mirau-based full-field optical coherence tomography system. Using two 520-nm laser diodes to pump the Ti:sapphire crystal fiber, ASE centered at 770 nm with a bandwidth of 164 nm was generated. The Mirau-based full field OCT has an axial resolution of 1.67 μm in air. A 10x mirau objective was employed, and achieved a lateral resolution of 1.65 μm. Using this system, we can measure in-vivo skin and get the high resolution 3D volume structure. Utilizing the low absorption light source, the penetration depth of in-vivo skin measurement is about 300 μm. We can use this high resolution OCT image to quantitize the thickness of stratum corneum and can distinguish the dermo-epidermal junction.
Subjects
Mirau-based full-field optical coherence tomography
In-vivo skin measurement
stratum corneum thickness
dermo-epidermal junction
SDGs
Type
thesis
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