Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan
Journal
Journal of the Formosan Medical Association
Journal Volume
105
Journal Issue
3
Pages
229-234
Date Issued
2006
Author(s)
Abstract
Background: Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan. Methods: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Results: Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test). Conclusion: These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan. ?2006 Elsevier & Formosan Medical Association.
Subjects
c-Jun activation; Oral cancer; Prognosis
SDGs
Other Subjects
paraffin; protein c jun; age; article; betel nut; cancer patient; cancer staging; cancer survival; carcinogenesis; controlled study; correlation analysis; disease association; female; gene activation; gene overexpression; human; human tissue; immunohistochemistry; Kaplan Meier method; log rank test; lymph node metastasis; major clinical study; male; mouth carcinoma; prognosis; sex difference; squamous cell carcinoma; Taiwan; tumor localization; tumor volume
Publisher
Scientific Communications International Ltd
Type
journal article