Single-shot proton MR spectroscopic inverse imaging
Date Issued
2014
Date
2014
Author(s)
Hsu, Yi-Ting
Abstract
Magnetic resonance spectroscopy (MRS) is a non-invasive technique that has been used to investigate the metabolic changes in living tissues. Fast magnetic resonance spectroscopy imaging (MRSI) using the proton-echo-planar-spectroscopy-imaging (PEPSI) technique can provide spatial distribution of metabolites in one single radio-frequency (RF) excitation. This method significantly reduces the scan time of 2-dimension MRSI down to 1 minute.
Inverse imaging (InI) uses a highly parallel RF coil array to achieve 100-millisecond temporal resolution with the whole brain coverage. Combining PEPSI sequence with InI can further accelerate the MRSI data acquisition. InI reconstruction utilizes coil sensitivities to reconstruct the omitted partition/phase encoded data by solving an under-determined inverse problem.
This study shows that the acceleration rate of the combined PEPSI and INI method is not as fast as expected. Specifically, using a 32-channel head coil array, we can achieve up to 6-fold acceleration in 2D PEPSI. Such scan time reduction can still increase the potential of applying MRSI to clinical applications.
Subjects
核磁共振影像
核磁共振頻譜
面回訊氫原子核磁共振頻譜
逆影像
射頻線圈
陣列線圈
Type
thesis
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