The cancer chemopreventive and therapeutic potential of tetrahydrocurcumin
Journal
Biomolecules
Journal Volume
10
Journal Issue
6
Date Issued
2020
Author(s)
Abstract
In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Cancer chemoprevention; Tetrahydrocurcumin
SDGs
Other Subjects
alcohol dehydrogenase; azoxymethane; catalase; curcumin; cyclin D1; cyclooxygenase 2; gelatinase B; glutathione; glutathione peroxidase; malonaldehyde; mitogen activated protein kinase p38; myeloperoxidase; nitric oxide; protein p53; sirtuin 1; superoxide dismutase; tetrahydrocurcumin; unclassified drug; antineoplastic agent; curcumin; tetrahydrocurcumin; Akt/mTOR signaling; antiinflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; binding affinity; biotransformation; cancer growth; cancer prevention; cancer research; cancer resistance; cancer therapy; carcinogenesis; cardiovascular disease; cell migration; cell proliferation; chemoprophylaxis; colony formation; cytotoxicity; DNA damage; DNA repair; DNA replication; DPPH radical scavenging assay; drug release; enzyme activity; gene expression; gene mutation; genetic transcription; genomic instability; hydrogen bond; IC50; intestine flora; iron chelation; lipid peroxidation; liver protection; MCF-7 cell line; molecular docking; oxidative stress; protein synthesis; Review; rheumatoid arthritis; signal transduction; systemic lupus erythematosus; tumor growth; tumor invasion; tumor suppressor gene; upregulation; human; neoplasm; Antineoplastic Agents; Curcumin; Humans; Neoplasms
Type
review