Monitoring liver function among patients who initiated antituberculosis drugs in Taiwan, 2000-2011
Journal
International Journal of Tuberculosis and Lung Disease
Journal Volume
18
Journal Issue
10
Pages
1245_1251
Date Issued
2014
Author(s)
Abstract
Objective: To investigate adherence to liver function monitoring as recommended in Taiwan's tuberculosis (TB) diagnosis and treatment guidelines for newly diagnosed TB patients.Design: Retrospective cohort study of the National Health Insurance Research Database (NHIRD), Taiwan, 2000-2011.Methods: From the NHIRD, we identified 11 397 newly diagnosed TB patients who initiated anti-tuberculosis treatment between 2000 and 2011 and categorised these into three groups: completely, partially and non-adherent. Logistic regression was used to explore potential factors associated with the adherence rate.Results: The completely adherent rate increased from 0.5% in 2000 to 9.2% in 2011, while the non-adherent rate decreased from 17.5% to 1.2%. Compared to the non-adherent group, patients with a history of liver disease (OR 4.36, 95%CI 1.92-9.87) and viral hepatitis (OR 9.39, 95%CI 1.47-60.19), as well as patients whose prescribing physicians were specialists in chest (OR 4.59, 95%CI 1.91-11.05), TB (OR 2.55, 95%CI 1.01-6.40) and infectious diseases (OR 3.93, 95%CI 1.08-14.31), had higher odds of being completely adherent to the guidelines.Conclusion: Our findings could serve as an important reference for developing effective strategies to improve adherence to guidelines and prevent patients from developing anti-tuberculosis drug-associated hepatotoxicity. ? 2014 The Union.
Subjects
Adherence; Hepatotoxicity; Liver function tests; Tuberculosis
SDGs
Other Subjects
tuberculostatic agent; tuberculostatic agent; adolescent; adult; aged; Article; child; cohort analysis; data base; female; human; infant; liver function test; logistic regression analysis; major clinical study; male; medical history; monitoring; newborn; population research; practice guideline; prescription; retrospective study; Taiwan; tuberculosis; virus hepatitis; drug effects; liver; Liver Diseases; liver function test; middle aged; pathophysiology; patient compliance; preschool child; statistical model; tuberculosis; young adult; Adolescent; Adult; Aged; Antitubercular Agents; Child; Child, Preschool; Female; Guideline Adherence; Humans; Infant; Liver; Liver Diseases; Liver Function Tests; Logistic Models; Male; Middle Aged; Patient Compliance; Retrospective Studies; Taiwan; Tuberculosis; Young Adult
Type
journal article