Profiling the fecal carriage of β-lactamase genes in long-term care facility residents: A longitudinal study
Journal
American Journal of Infection Control
Journal Volume
44
Journal Issue
11
Pages
e227-e233
Date Issued
2016
Author(s)
Abstract
Background The fecal carriage of β-lactamase (BL)–producing bacteria may play a major role in the spread of these organisms in long-term care facilities (LTCFs). The aims of this study were (1) to describe the gene profiles of fecal BL in 3 LCTFs in Taiwan and (2) to analyze the fecal carriage burden of BL genes between the residents (patient group) and staff (staff group) of LTCFs. Methods Thirty fecal samples were collected during June 2013 and July 2015: 20 were obtained from 10 residents both during hospitalization (T1) and 1 month after discharge (T2), and 10 were obtained from 10 staff members. Results In total, 80%, 70%, and 50% of the samples in the patient group at T1, staff group at T2, and patient group at T2, respectively, contained >2 BL genes. In the patient group, the predominant genes belonged to extended-spectrum BL genes (90%-100%) and AmpC BL genes (90%-100%). Furthermore, carbapenemase genes were approximately 20% during T1 and T2. The relative levels of SHV-type BLs were significantly higher (P?
Subjects
Fecal carriage; long-term care facility; longitudinal study; β-lactamase genes
SDGs
Other Subjects
amikacin; amoxicillin plus clavulanic acid; beta lactam; beta lactamase ACC; beta lactamase AmpC; beta lactamase CTXM Gp1; beta lactamase CTXM Gp2; beta lactamase CTXM Gp9; beta lactamase CTXM MG8 25; beta lactamase GES; beta lactamase OXA 1 like; beta lactamase PER; beta lactamase SHV; beta lactamase VEB; carbapenemase; cefalexin; cefazolin; cefoxitin; ceftibuten; ceftriaxone; ciprofloxacin; extended spectrum beta lactamase; flomoxef; fluconazole; levofloxacin; piperacillin; piperacillin plus tazobactam; sultamicillin; tigecycline; unclassified drug; vancomycin; beta lactamase; aged; antibiotic therapy; Article; bacteremia; clinical article; community hospital; controlled study; DNA sequence; feces analysis; female; follow up; gene expression profiling; health care facility; heterozygote; hospitalization; human; Klebsiella pneumoniae; long term care; longitudinal study; male; multicenter study; pneumonia; polymerase chain reaction; prevalence; Pseudomonas aeruginosa; risk factor; staff; Staphylococcus aureus; Streptococcus; Taiwan; upper gastrointestinal bleeding; urinary tract infection; very elderly; bacterial infection; feces; genetics; heterozygote; microbiology; Aged; Aged, 80 and over; Bacterial Infections; beta-Lactamases; Carrier State; Feces; Female; Humans; Long-Term Care; Longitudinal Studies; Male; Prevalence; Taiwan
Publisher
Mosby Inc.
Type
journal article