Association study of serotonin receptor and transporterene polymorphisms with tardive dyskinesia in chronic schizophrenia
Date Issued
2009
Date
2009
Author(s)
Hiseh, Ching-Jow
Abstract
Background and Objective: Tardive dyskinesia (TD) is a serious side effect of antipsychotics. Although the pathogenesis of TD is still not fully understood, studiesave reported TD is associated with serotonin genes. This study is aimed at exploring the association between the serotonin gene polymorphisms (HTR2A T102C, 5-HTTLPR, HTR2C Cys23Ser) and chronic schizophrenic patients with or withoutD.ethods: Genetic association study with case control design was performed to analyze the allele and genotype frequencies of schizophrenia patients with TD (n=32),atients without TD (n=135), and normal control participants (n=91). All participants are Ethnic Han Taiwanese. Genotyping of HTR2A T102C polymorphism, 5-HTTLPRolymorphism and HTR2C Cys23Ser polymorphism were performed by polymerase chain reaction-based restriction analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed by multivariate logistic regression analysis. Subgroup analysis was performed according to age and gender.esults: The C allele frequency of HTR2A is 29.7% in TD group and 45.6% in non-TD group (P=0.021). Patients carrying C allele were likely to be protected fromD (OR=0.26, 95% CI=0.10-0.71, P=0.008 for dominant mode; OR=0.40, 95% CI=0.19-0.86, P=0.019 for additive mode). However, no association between 5-HTTLPR and HTR2C polymorphisms and TD was found. HTR2A T102C was associated with TD in subgroup of older than 50 years (OR=0.28, 95% CI=0.10-0.84, P=0.022) and men (OR=0.033, 95% CI=0.003-0.37, P=0.006).onclusion: Our findings support that HTR2A T102C polymorphism influences the susceptibility to antipsychotics-induced TD in the chronic schizophrenic patients in Taiwan.
Subjects
Tardive dyskinesia
Schizophrenia
Serotonin 2A receptor gene
Serotonin transporter gene
Serotonin 2C receptor gene
Polymorphism
Type
thesis
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