Evaluation of rare and common variants from suspected familial or sporadic nasopharyngeal carcinoma (NPC) susceptibility genes in sporadic NPC
Journal
Cancer Epidemiology Biomarkers and Prevention
Journal Volume
28
Journal Issue
10
Pages
1682-1686
Date Issued
2019
Author(s)
Liu Z.
Goldstein A.M.
Hsu W.-L.
Yu K.J.
Chien Y.-C.
Jian J.J.-M.
Tsou Y.-A.
Leu Y.-S.
Liao L.-J.
Chang Y.-L.
Wu J.-S.
Hua C.-H.
Lee J.-C.
Tsai M.-H.
Huang K.-K.
Yu K.
Jones K.
Zhu B.
Yeager M.
Yu G.
Chen C.-J.
Hildesheim A.
for the GEV-NPC group
Abstract
BACKGROUND: Genetic susceptibility is associated with nasopharyngeal carcinoma (NPC). We previously identified rare variants potentially involved in familial NPC and common variants significantly associated with sporadic NPC. METHODS: We conducted targeted gene sequencing of 20 genes [16 identified from the study of multiplex families, three identified from a pooled analysis of NPC genome-wide association study (GWAS), and one identified from both studies] among 819 NPC cases and 938 controls from two case-control studies in Taiwan (independent from previous studies). A targeted, multiplex PCR primer panel was designed using the custom Ion AmpliSeq Designer v4.2 targeting the regions of the selected genes. Gene-based and single-variant tests were conducted. RESULTS: ) for NPC risk. In addition, we validated four previously reported NPC risk-associated SNPs. CONCLUSIONS: Our findings confirm previously reported associated variants and suggest that some common variants in genes previously linked to familial NPC are associated with the development of sporadic NPC. IMPACT: , suggest a role for telomere length maintenance in NPC etiology.
SDGs
Publisher
American Association for Cancer Research Inc.
Type
journal article