No association of G72 and d-amino acid oxidase genes with schizophrenia
Journal
Schizophrenia Research
Journal Volume
87
Journal Volume
87
Journal Issue
1-3
Journal Issue
1-3
Pages
15-20
Start Page
15
End Page
20
ISSN
0920-9964
Date Issued
2006-10
Author(s)
Liu Y.-L.
Fann C.S.-J.
Chang C.C.
Wu J.-Y.
Hung S.-I.
Liu S.-K.
Chan H.-Y.
Chen J.-J.
Faraone S.V.
Tsuang M.T.
Abstract
The genes of d-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-d-aspartate receptor regulation pathway for schizophrenia. In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia. In SNP-based single locus association analyses, neither G72 nor DAAO showed significant association with schizophrenia. Additionally, a three-SNP haplotype in DAAO, and a four-SNP as well as a two-SNP haplotype in G72, showed no significant associations with schizophrenia. These results suggest that the DAAO and G72 genes are not susceptibility genes for schizophrenia in a Taiwanese sample. ? 2006 Elsevier B.V. All rights reserved.
SDGs
Other Subjects
dextro amino acid oxidase; dextro amino acid oxidase activator protein; protein; unclassified drug; article; disease association; family; gene locus; genetic susceptibility; genotype; haplotype; human; major clinical study; matrix assisted laser desorption ionization time of flight mass spectrometry; priority journal; schizophrenia; sibling; single nucleotide polymorphism; Taiwan; Carrier Proteins; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 13; D-Amino-Acid Oxidase; Gene Frequency; Genetic Markers; Genotype; Haplotypes; Humans; Polymorphism, Single Nucleotide; Schizophrenia; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taiwan
Type
journal article