Fecal elastase 1, serum amylase and lipase levels in children with cholestasis
Journal
Pancreatology
Journal Volume
5
Journal Issue
4��5��
Pages
432-437
Date Issued
2005
Author(s)
Abstract
Background/Aim: The pancreatic functions of children with cholestatic liver diseases were unclear. Due to anatomic vicinity and common ontogenic origin, hepatobiliary disorders of infancy may also affect pancreatic function. The aim of the study was to evaluate the exocrine pancreatic function and common pancreatic function tests in children with cholestatic disorders. Methods: In 40 children with cholestasis, fecal elastase 1 (FE1) concentrations were measured. Serum amylase and lipase values were tested. The diagnoses included 32 patients with extrahepatic cholestasis (biliary atresia (BA) and choledochal cyst), and 8 patients with intrahepatic cholestasis (progressive familial intrahepatic cholestasis and Alagille syndrome). None had renal insufficiency or clinical symptoms/signs of acute pancreatitis. Results: All the patients had normal FE1 (>200 μg/g). Nineteen percent (7/37) had elevated serum amylase levels (>100 U/l). Thirty-two percent (12/37) had elevated serum lipase levels above the normal (>120 U/l). Seventy-three percent (8/11) of BA patients with bilirubin >2 mg/dl had elevated serum lipase levels compared to 18% (3/17) with bilirubin ?2 mg/dl (p = 0.0036). None had detectable pancreatic abnormality on ultrasonography and magnetic resonance images. Conclusions: None of the cholestatic children in this study had exocrine pancreatic insufficiency as detected by FE1. Hyperamylasemia and/or hyperlipasemia were frequently found. In children with BA, those with impaired biliary excretion tended to have elevated serum pancreatic enzymes as compared with those who had no jaundice. A decreased hepatic metabolism may be the cause. Copyright ? 2005 S. Karger AG and IAP.
SDGs
Other Subjects
amylase; bilirubin; elastase i; isoenzyme; triacylglycerol lipase; unclassified drug; acute pancreatitis; Alagille syndrome; amylase blood level; article; bile duct atresia; bilirubin blood level; child; cholendochal cyst; cholestasis; clinical article; clinical feature; controlled study; cyst; echography; feces level; female; human; infant; intrahepatic cholestasis; kidney failure; male; nuclear magnetic resonance imaging; pancreas disease; pancreas function; pancreatography; priority journal; triacylglycerol lipase blood level
Publisher
Elsevier B.V.
Type
journal article