Pre-clinical tests of an integrated CMOS biomolecular sensor for cardiac diseases diagnosis
Journal
Sensors (Switzerland)
Journal Volume
17
Journal Issue
12
Date Issued
2017
Author(s)
Abstract
Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 _m CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis. ? 2017 by the authors. Licensee MDPI, Basel, Switzerland.
SDGs
Other Subjects
Bioassay; Biological organs; Biosensors; Cardiology; Diagnosis; Diseases; Health risks; Heart; Peptides; Brain natriuretic peptide; CMOS biosensors; Field effects; Heart disease; Interleukin-6; Troponin i; CMOS integrated circuits; biological marker; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); troponin I; coronary artery disease; genetic procedures; human; Biomarkers; Biosensing Techniques; Coronary Artery Disease; Humans; Natriuretic Peptide, Brain; Peptide Fragments; Troponin I
Publisher
MDPI AG
Type
journal article