Population-based screening program for reducing oral cancer mortality in 2,334,299 Taiwanese cigarette smokers and/or betel quid chewers
Journal
Cancer
Journal Volume
123
Journal Issue
9
Pages
1597-1609
Date Issued
2017
Author(s)
Chuang S.-L.
Su W.W.-Y.
Chen S.L.-S.
Yen A.M.-F.
Fann J.C.-Y.
Chiu S.Y.-H.
Chang D.-C.
Jou Y.-Y.
Wu C.-Y.
Chen M.-K.
Chiou S.-T.
Abstract
BACKGROUND: To reduce oral cancer mortality, an organized, population-based screening program for the early detection of oral premalignancy and oral cancer was designed for high-risk individuals with habits of betel quid chewing, cigarette smoking, or both. The objective of this report was to evaluate the long-term effectiveness of this program in reducing the incidence of advanced disease and deaths from oral cancer. METHODS: A nationwide, population-based screening program for oral cancer has been conducted in Taiwan since 2004. Residents aged ? 18 years with oral habits of cigarette smoking and/or betel quid chewing were invited. The standardized mortality ratio method was used to compare the observed numbers of advanced oral cancers and deaths from oral cancer among screening attendees with the expected numbers derived from mortality among nonattendees. An intention-to-treat analysis of the relative rate of reductions in advanced-stage oral cancers and oral cancer mortality also was conducted. RESULTS: The overall screening rate was 55.1%. The relative risk of death from oral cancer was 0.53 (95% confidence interval [CI], 0.51-0.56) as a result of screening compared with the expected risk of oral cancer deaths in the absence of screening. The corresponding relative risk was 0.74 (95% CI, 0.72-0.77) after adjusting for self-selection bias. The relative risk of advanced oral cancer for the screened group versus the nonscreened group was 0.62 (95% CI, 0.59-0.64), which increased to 0.79 (95% CI, 0.76-0.82) after adjustment for self-selection bias. CONCLUSIONS: An organized, population-based oral cancer screening program targeting more than 2 million Taiwanese cigarette smokers and/or betel quid chewers demonstrated the effectiveness of reducing stage III or IV oral cancers and oral cancer mortality. These evidence-based findings corroborate and support the screening strategy of oral visual inspection for the prevention of oral cancer among high-risk individuals in areas with a high incidence of oral cancer. Cancer 2017;123:1597–1609. ? 2017 American Cancer Society. ? 2017 American Cancer Society
SDGs
Other Subjects
adult; advanced cancer; aged; Article; betel quid chewing; cancer mortality; cancer screening; early cancer diagnosis; erythroleukoplakia; erythroplasia; female; high risk population; human; leukoplakia; male; mortality rate; mouth cancer; precancer; predictive value; smoking; standardized mortality ratio; substance use; Taiwanese; verrucous hyperplasia; adolescent; Areca; information retrieval; Leukoplakia, Oral; middle aged; mortality; Mouth Neoplasms; pathology; Precancerous Conditions; procedures; register; Taiwan; young adult; Adolescent; Adult; Aged; Areca; Early Detection of Cancer; Female; Humans; Information Storage and Retrieval; Leukoplakia, Oral; Male; Middle Aged; Mouth Neoplasms; Precancerous Conditions; Registries; Smoking; Taiwan; Young Adult
Publisher
John Wiley and Sons Inc.
Type
journal article