The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome
Journal
PLoS ONE
Journal Volume
14
Journal Issue
2
Pages
e0212341
Date Issued
2019
Author(s)
Abstract
Spot 14 (S14) protein is primarily expressed in adipogenic tissues. Compared to wild type, S14 knockout mice had better resistance to diet-induced obesity and glucose tolerance. However, the association between serum S14 level and metabolic variables in humans has never been investigated. The objectives of this study were to evaluate the associations between serum S14 concentrations with components of metabolic syndrome (MetS). A total of 327 subjects were recruited in this cross-sectional study and categorized by presence of MetS. The mean serum levels of S14 were significantly lower in subjects with MetS than those without (87.1±26.3 μg/L vs. 107.3±40.2 μg/L, p<0.001). In addition, the subjects with central obesity, low high density lipoprotein-C (HDL-C) or hypertriglyceridemia also had significantly lower S14 levels in comparison to those without. Adjusted with age and sex, diagnosis of MetS (β = -0.227, p<0.001), central obesity (β = -0.176, p = 0.001), low HDL-C (β = -0.149, p = 0.005), and high triglyceride (TG) (β = -0.198, p<0.001) were negatively associated with log transformation of serum S14 levels (logS14). With 25% logS14 increased, the risk of MetS (OR 0.65, 95% CI, 0.51–0.82, p<0.001), central obesity (OR 0.72, 95% CI, 0.58–0.89, p = 0.002), low HDL-C (OR 0.76, 95% CI, 0.61–0.95, p = 0.015) or high TG (OR 0.65, 95% CI, 0.51–0.83, p = 0.001) was reduced with a dose response trend. Our analysis revealed that patients with MetS had lower serum S14 levels than those without. Negative associations existed between MetS, central obesity, high TG, low HDL-C and logS14. ? 2019 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SDGs
Other Subjects
lipogenic protein; low density lipoprotein cholesterol; proteolipid protein; Spot 14 protein; triacylglycerol; unclassified drug; low density lipoprotein cholesterol; nuclear protein; THRSP protein, human; transcription factor; triacylglycerol; adult; Article; cholesterol blood level; controlled study; cross-sectional study; female; high risk population; human; hypertriglyceridemia; major clinical study; male; metabolic syndrome X; middle aged; obesity; predictive value; protein blood level; protein function; risk assessment; risk factor; triacylglycerol blood level; abdominal obesity; aged; blood; complication; metabolic syndrome X; odds ratio; pathology; statistical model; Adult; Aged; Cholesterol, LDL; Cross-Sectional Studies; Female; Humans; Linear Models; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Nuclear Proteins; Obesity, Abdominal; Odds Ratio; Risk Factors; Transcription Factors; Triglycerides
Publisher
Public Library of Science
Type
journal article