Association between mean corpuscular volume and cognitive function in community-dwelling older adults: An 8-year cohort study
Journal
Journal of the Formosan Medical Association
ISSN
0929-6646
Date Issued
2025-12
Author(s)
Abstract
BACKGROUND: Larger mean corpuscular volume (MCV) may indicate impaired oxygen and nutrient delivery to the brain, and could be associated with cognitive impairment, yet longitudinal evidence remains limited. This study investigated this association in community-dwelling older adults. METHOD: This prospective cohort study (2011-2022) was from the Taiwan Initiative for Geriatric Epidemiological Research at baseline with four biennial follow-ups. Global cognition was assessed longitudinally using the Montreal Cognitive Assessment, Taiwanese version, and domain-specific cognition via a battery of neuropsychiatric tests. Red cell distribution width (RDW), hemoglobin, platelet, and vitamin B12 were also collected. Generalized linear mixed models were utilized to analyze the association between baseline MCV and cognition adjusting for covariates. RESULTS: = 0.04) was observed. CONCLUSION: Elevated baseline MCV was associated with poor cognition, especially in memory and attention domains, over time. Future longitudinal studies are warranted to confirm this temporal relationship.
SDGs
Publisher
Elsevier BV
Type
journal article