Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very-low-birthweight infants
Journal
Developmental Medicine and Child Neurology
Journal Volume
50
Journal Issue
1
Pages
51-57
Date Issued
2008
Author(s)
Hsu C.-H.
Kao H.-A.
Hung H.-Y.
Chang J.-H.
Chiu N.-C.
Hsieh W.-S.
Abstract
This study examined the developmental and clinical outcomes in very-low-birthweight (VLBW;?1500g) infants with and without bronchopulmonary dysplasia (BPD) throughout infancy, and assessed if BPD predicted poor developmental outcome beyond the effects of other risk factors. One hundred and three VLBW infants (53 males, 50 females; mean gestational age 28wks [SD 2] birthweight 1041g [SD 261]) were graded for severity of BPD according to the American National Institutes of Health (NIH) consensus definition. Neuro-development was assessed using the Neonatal Neurobehavioral Examination-Chinese version, at 36 and 39 weeks' postmenstrual age, and the 2nd edition of the Bayley Scales of Infant Development at 6 and 12 months' corrected age. Clinical outcome was measured by means of rehospitalization for pulmonary causes and treatment with pulmonary medications. Compared with infants without BPD, infants with BPD had higher rates of clinical morbidity, and those with severe BPD further exhibited higher incidences of developmental delay throughout infancy. BPD predicts poor 1-year developmental and clinical outcomes in VLBW infants for which effects are well correlated to the NIH consensus definition. ? 2008 Blackwell Publishing Ltd.
SDGs
Other Subjects
article; consensus; controlled study; correlation coefficient; demography; developmental disorder; disease association; disease severity; female; hospital readmission; human; incidence; infant; lung dysplasia; major clinical study; male; morbidity; prediction; priority journal; prognosis; rating scale; risk factor; Taiwan; very low birth weight; Bronchopulmonary Dysplasia; Case-Control Studies; Child, Preschool; Cohort Studies; Developmental Disabilities; Female; Hospitalization; Humans; Incidence; Infant; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Male; Risk Factors; Severity of Illness Index
Type
journal article