Glial nrf2 signaling mediates the neuroprotection exerted by gastrodia elata blume in lrrk2-g2019s parkinson’s disease
Journal
eLife
Journal Volume
10
Pages
e73753
Date Issued
2021
Author(s)
Abstract
transgenic mice with WGE and found that the locomotion declines, the loss of dopaminergic neurons, and the number of hyperactive microglia were restored. WGE also suppressed the hyperactivation of G2019S proteins and regulated the Smad2/3 pathways in the mice brains. We conclude that WGE prevents locomotion defects and the neuronal loss induced by G2019S mutation via glial Nrf2/Mad signaling, unveiling a potential therapeutic avenue for PD.
SDGs
Type
journal article