Monitoring Power Performance in the Family-Based Association Study
Date Issued
2004
Date
2004
Author(s)
Wang, Ya-Ting
DOI
zh-TW
Abstract
本研究根據最簡單的三元體家庭資料，模擬當只考慮父母之一標識對偶基因為異質基因型的家庭時，在特定疾病基因頻率、標識基因頻率及遺傳模式下，利用TDT統計量求出檢定力。再應B-值統計量可以依目前所收資料推測結果趨勢之特性，估計出若家庭資料收集至預期樣本數時之條件檢定力。最後，將比較TDT統計量所得之檢定力與經由B-值統計量觀念所得條件檢定力之關係。
Transmission/disequilibrium test (TDT) is a commonly used method for analysis of linkage. The basis data unit used for TDT method is the case-parent triad family. Since collection of triad families could be sequentially in practical study, it is interesting to develop power-monitoring procedure for TDT testing procedure. In this paper, we use the B-Value statistic to accomplish the goal. The sequential monitoring procedure is illustrated with some examples under various genetic models.
Subjects
B-值
TDT統計量
條件檢定力
樣本數
conditional power
sample size
TDT statistic
B-Value
Type
thesis