Blood glucose promotes dengue virus infection in the mosquito Aedes aegypti
Journal
Parasites & vectors
Journal Volume
14
Journal Volume
14
Journal Issue
1
Journal Issue
1
Start Page
article 376
Date Issued
2021-07-26
Author(s)
Abstract
Dengue fever is the most rapidly spreading mosquito-borne viral disease globally. More than 2.5 billion people live in dengue-endemic areas. Previous studies suggested an interrelationship between diabetes mellitus (DM) and dengue hemorrhagic fever (DHF). Conversely, glycolysis is a critical metabolic pathway for optimal dengue virus (DENV) replication. However, little is known concerning the effect of glucose on DENV replication in mosquitoes. In this study, we investigated the impact of glucose on DENV replication in mosquitoes Aedes aegypti.
Subjects
Aedes aegypti; Dengue virus; Glucose; Signaling pathway
SDGs
Other Subjects
double stranded RNA; glucose; mammalian target of rapamycin; protein kinase B; viral protein; Aedes aegypti; Akt/mTOR signaling; animal cell; animal experiment; Article; comorbidity; controlled study; dengue; disease transmission; female; gene expression; glucose blood level; mouse; nonhuman; saliva; serotype; upregulation; virus genome; virus load; virus replication; Western blotting; Aedes; animal; dengue; Dengue virus; drug effect; human; mosquito vector; physiology; RNA interference; signal transduction; virology; Aedes; Animals; Blood Glucose; Dengue; Dengue Virus; Female; Humans; Mosquito Vectors; RNA Interference; Serogroup; Signal Transduction; Virus Replication
Publisher
BMC
Type
journal article