Electrophoretic Mobility of Biological Cells in Asymmetric Electrolyte Solutions
Resource
J. theor. Biol. 182, 137-145
Journal
Journal of Theoretical Biology
Pages
137-145
Date Issued
1996
Date
1996
Author(s)
DOI
246246/2006111501275508
Abstract
The electrophoretic mobility of a particle covered by a membrane in an a:b electrolyte solution is modeled theoretically. The membrane, which simulates the surface of a biological cell, is ion-penetrable, and carries homogeneously distributed negative fixed charges. An approximate expression for the electrophoretic mobility is derived. Based on the results of numerical simulation, we conclude the following: (1) The absolute Donnan potential increases with the concentration of the fixed charges C0, but decreases with the ionic strength I. (2) The greater the valence of cation alpha, the lower the absolute potential distribution. (3) The greater the C0, the greater the absolute mobility of a particle, magnitude of mu, and the greater the friction coefficient of the membrane phase gamma, the smaller the magnitude of mu. (4) A large I or a large a leads to a small magnitude of mu. (5) The greater the ratio (permittivity of solution/permittivity of membrane phase), the smaller the magnitude of mu. (6) For a large gamma, magnitude of mu decreases with the thickness of membrane d under the condition of constant amount of fixed charges. However, if gamma is sufficiently small, the variation of magnitude of mu as a function of d exhibits a maximum. The classic result of Smoluchowski for the electrophoretic mobility of a rigid particle can be recovered as a limiting case of the present model.
Publisher
Taipei:National Taiwan University Dept Phys
Type
journal article
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