Bioinformatic Study on Characteristics of Cohesion Associated Regions
Date Issued
2004
Date
2004
Author(s)
Chen, Chun-Chang
DOI
en-US
Abstract
Mitosis is a very important phenomenon of life. In the mitosis of cells, cohesion connects the newly duplicated chromosomes (sister chromatids) from the S phase to anaphase to ensure the correct splitting and distribution of the genome. Recently, many proteins that control cohesion have been discovered. However, most knowledge about the characteristics of cohesion associated regions (CARs) has been gained from experiments on individual CARs.
This study seeks to identify the characteristics of CARs by means of a computational approach. We review the literature and obtain a list of potential factors that may associate with CARs, including the intergenic regions of WC orientation, scaffold/matrix attachment regions (S/MARs), autonomously replicating sequences (ARS), palindrome, tRNA genes, yeast retrotransposons and nearby long terminal repeats (LTRs). We define a distance measure and propose a probabilistic model to investigate the association of each potential factor with CARs. We find that the intergenic regions of WC orientation, palindromes, S/MARs, tRNA genes and ARS do not randomly colocalize with CARs under the 95% confidence level.
Subjects
凝聚 (Cohesion)
自主複製序列(ARS)
長終端重複區(Long terminal repeats)
異染色質絲(Heterochromatin)
基因方向(Gene orientation)
反轉序列(Palindrome)
核骨架結合核醣核酸片段(S/MAR)
屏障(Barriers)
Long terminal repeats
Scaffold/Matrix attachment regions
Cohesin
Cohesion
Palindrome
Barriers
Gene orientation
Heterochromatin
Autonomously replicating sequences
Type
other
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