Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
Journal
Journal of biomedical science
Journal Volume
28
Journal Issue
1
Date Issued
2021-11-10
Author(s)
Cheng, Yung-Ming
Lee, Chang-Cheng
Kao, Chiu-Hwa
Chan, Kuang-Yu
Chen, Yeh-Ting
Hsu, Wen-Ling
Abstract
A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon-γ (IFN-γ)/ Janus kinase (JAK)/ signal transducer and activator of transcription (STAT)1 pathway provide new directions in this regard.
Subjects
Colorectal cancer; Interferon-γ (IFN-γ); Major histocompatibility complex (MHC) class I; Proteasome inhibitors; STAT1; Tumor infiltrating lymphocytes (TILs)
Publisher
BMC
Type
journal article