Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models
Journal
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Journal Volume
12744 LNCS
Pages
670-683
Date Issued
2021
Author(s)
Abstract
Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupling of a one-dimensional arterial blood flow model and a three-dimensional tissue perfusion model. The two-way coupling occurs through the pial surface, where the pressure drop between the models is captured using a coupling resistance. The two-way coupled model is used to simulate arterial blood flow and tissue perfusion during an acute ischaemic stroke. Infarct volume is estimated by setting a threshold on the perfusion change. By two-way coupling these two models, the effect of retrograde flow and its effect on tissue perfusion and infarct volume can be captured. ? 2021, Springer Nature Switzerland AG.
Subjects
Blood
Hemodynamics
One dimensional
Tissue
Arterial blood
Coupled modeling
Coupling resistance
Multiple scale
Perfusion models
Retrograde flow
Tissue perfusion
Two-way coupling
Tissue engineering
Type
conference paper