Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia
Journal
Planta Medica
Journal Volume
71
Journal Issue
11
Pages
1078-1081
Date Issued
2005
Author(s)
Abstract
A new acetophenone derivative, melicopone, along with twenty-nine known compounds has been isolated from the root wood of Melicope semecarpifolia. The structure of this new compound was determined using spectral analyses. The compound oxynitidine isolated in this study adds the Melicope genus to the benzo[c]phenanthridine-containing members chemotaxonomically. Three isolates were cytotoxic in P-388 and HT-29 cell lines, and anti-platelet aggregation activities were shown for 10 known compounds. ? Georg Thieme Verlag KG Stuttgart.
SDGs
Other Subjects
2,6 dimethoxy 4 benzoquinone; 4 ketopinoresinol; 7 o prenylumbelliferone; 7,8 dimethoxymyrtopsine; 7,8 dimethoxyplatydesmine; acetophenone derivative; angelicin; antithrombocytic agent; ayanin; benzoic acid; brosiparin; columbianetin; cytotoxic agent; dictamnine; edulinine; jatamsinol; kokusaginine; Melicope semecarpifolia extract; melicopone; mithramycin; oroselol; osthenol; oxynitidine; phenanthridine derivative; plant extract; platydesmine; pteleine; seselin; unclassified drug; unindexed drug; vanillin; antineoplastic activity; article; cancer cell culture; chemotaxonomy; controlled study; drug cytotoxicity; drug isolation; human; human cell; leukemia P 388; medicinal plant; Melicope semecarpifolia; nonhuman; plant root; structure activity relation; thrombocyte aggregation inhibition; Acetophenones; Antineoplastic Agents; Benzaldehydes; Benzoic Acid; Coumarins; Flavonoids; HT29 Cells; Humans; Lignans; Molecular Structure; Plant Extracts; Plant Roots; Platelet Aggregation Inhibitors; Quinolines; Rutaceae; Melicope; Melicope semecarpifolia
Type
journal article