Identification of Interface Residues Based on PSSM Profile and Biochemical Properties
Date Issued
2006
Date
2006
Author(s)
Hsiao, Chun-Lu
DOI
zh-TW
Abstract
Protein interactions play an important role in bioinformatics since they mediate the assembly of macromolecular complexes, or the sequential transfer of information along signaling pathways. To understand the molecular basis of these functions and of protein networks, it is important to identify the individual protein interface.
In the post-genomics era, the known protein sequences are increasingly but the relative increasing rate of the solved protein structures is lower. Therefore, it’s meaningful to predict the protein interface from their sequences, and also the prediction can be benefit to construct the conformation of one protein which is bound to another under a certain conditions.
In recent years, more and more studies focus on the prediction of protein interface from protein sequences directly. Many methods among these studies are developed according to the different kinds of protein interface. However, fewer methods are used to predict without classifying the protein interface into several categories. In my thesis, the compositions and conserved functions of the amino acids in the protein interface are studied and also the information of secondary structures is added. Last, we use radio basis function network to predict the protein interface and the results of experiment are also shown that these feature sets are useful for the prediction.
Subjects
作用區段
interface residues
Type
thesis
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