Revised cutoff values of serum aminotransferase in detecting viral hepatitis among CAPD patients: Experience from Taiwan, an endemic area for hepatitis B
Journal
Nephrology Dialysis Transplantation
Journal Volume
12
Journal Issue
1
Pages
180-183
Date Issued
1997
Author(s)
Abstract
Background. To determine the best cutoff values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in detecting viral hepatitis C infection among patients of continuous ambulatory peritoneal dialysis (CAPD). Methods. 90 (44 male and 46 female) CAPD patients and 526 adult controls (266 male, 260 female) were enrolled. Serum AST and ALT were measured by an auto-analyser monthly. Serum HBsAg was examined using a RIA method and anti-HCV by an second-generation EIA method. The best cutoff values of AST and ALT for detecting viral hepatitis were obtained from the ROC (receiver-operating characteristic) curve. Results. The prevalence of anti-HCV(+) was significantly higher in CAPD patients (16.7%) than in normal controls (4.9%), while that of HBsAg(+) was similar in both groups. CAPD patients had significantly lower levels of serum aminotransferases compared to normal controls. Mean AST were 23.8 IU/1 in normal control and 18.8 IU/1 in the CAPD patients (P < 0.001). Mean ALT were 21.9 IU/1 in normal controls and 15.3 IU/1 in the CAPD patients (P < 0.001). CAPD patients with HCV infection had higher serum AST and ALT levels than those without. However, HBV infection did not cause significant serum aminotransferase elevation in patients. The conventional cutoff values of AST (40 IU/1) and ALT (40 IU/I) for detecting viral hepatitis yielded only a sensitivity of 27.3 and 18.2% respectively; on the contrary, our revised cutoff values of AST (24 IU/1) and ALT (17 IU/1) had better sensitivities (AST, 72.7%; ALT, 63.6%). For serial aminotransferase values, the sensitivity of AST and ALT for detecting HCV were 36.4 and 27.3% by conventional criteria, and were both 81.8%, by our newly revised criteria. Conclusions. Serum aminotransferase cutoff values should be modified for screening viral hepatitis in a CAPD population. Our new cutoff criteria had important clinical implications in providing benefits of earlier detection and possible prevention from chronic hepatic deteriorations.
SDGs
Other Subjects
alanine aminotransferase; aspartate aminotransferase; hepatitis b surface antigen; hepatitis c antibody; adult; aged; alanine aminotransferase blood level; article; aspartate aminotransferase blood level; continuous ambulatory peritoneal dialysis; female; hepatitis c; human; major clinical study; male; priority journal; screening; taiwan; virus detection; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis C Antibodies; Humans; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; ROC Curve; Sensitivity and Specificity; Taiwan
Type
journal article