台灣地區登革病毒感染的分子流行病學與化學激素的角色(2/2)
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
金傳春
DOI
912320B002081
Abstract
Mechanism of immunopathogenesis in leading to dengue hemorrhagic fever (DHF)
versus mild form of dengue fever (DF) during the same epidemic has not been fully
understood. The specific aims of this study were to determine whether there are
differences in the levels of chemokines (RANTES, Mig and MIP-1a ) associated with
hemorrhage between DHF and DF patients or clinical complications.
A prospective cohort study recruited 23 DHF and 77 DF patients caused by dengue
virus serotype 2 plus 46 healthy donors from Aug. 2 to Mar. 31, 2003 in Kaohsiung
and Pingtung. Levels of RANTES, Mig, MIP-1a were measured in serum samples
collected at both the first visit and subsequent repeated visits. Mann-Whitney U and
Spearman correlation test were used to compare the relationship between above each
chemokine and clinical status of DF vs DHF or hemodynamic/ biochemical laboratory
results, and their kinetic changes at different time points after the onset of fever,
respectively.
Ratios of CD4/CD3+T cells in DF patients was lower significantly compared to
healthy controls (DF patients: 33.19+ 2.21 vs healthy controls: 40.13 + 15.94, P=0.03).
There were higher serum levels of RANTES ( DHF: 13.69+3.46 vs DF: 19.56+2.74,
P=0.14), Mig (DHF: 653.45+ 85.89 vs DF: 664.63+ 59.60, P=0.23) and lower levels
of MIP-1a (DHF: 26.99+ 11.56 vs DF: 38.59+ 9.86, P=0.56). However, serum levels
of RANTES, Mig were significantly higher than healthy controls (P<0.05), whereas
levels of MIP-1a in dengue patients were significantly lower than compared to healthy
controls (P<0.05). The serum levels of chemokine were also compared after fever
onset. Levels of Mig in DHF and DF patients after fever onset 7 days were higher ≦
than that after fever onset >7 days. In contrast, levels of RANTES in DHF and DF
patients were lower after fever onset 7 days than that after fever onset >7 days.≦.
In conclusion, the serum chemokine kinetic patterns of DHF were different from
DF patients. These effects may lead to infected cells damages and then cause
hemorrhage. A closer examination of the production of these chemokines and the
activation of dengue virus infected target cells in the early phase of dengue virus
infection is warranted to attain a better understanding of immunopathgenesis of DHF.
Subjects
Dengue hemorrhagic fever
Innate Immunity
Immunological Responses
Chemokine
Taiwan
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
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